Brian R. Chapados

http://chapados.org
brian@chapados.org

education & training

• June, 2006

  Attended the Complex Systems Summer School at the Santa Fe Institute

• 2005-present

  Research Associate at The Scripps Research Institute with Professor John Tainer

• 1999-2005

  Ph.D. in Macromolecular and Cellular Structure and Chemistry. The Scripps Research Institute, La Jolla, California. Thesis work with Professor John A. Tainer entitled:
  “Substrate Recognition and Regulation of Structure-Specific Nucleases Central to DNA Replication and Repair.”

• 1995-1999

  BS in Recombinant Gene Technology. State University of New York at Fredonia, Fredonia, New York. Graduated summa cum laude.

• 1991-1995

  Niagara Wheatfield High School. Sanborn, New York. Regents Diploma with honors.

publications

• Zeitlin SG, Baker NM, Chapados BR, Soutoglou E, Wang JY, Berns MW, Cleveland DW. 2009. Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc. Natl. Acad. Sci. USA. 106: 15762 - 15767.

• Syson K, Tomlinson B, Chapados BR, Sayers JR, Tainer JA, Williams NH, Grasby JA. 2008. Three metal ions participate in the reaction catalyzed by T5 flap endonuclease. J. Biol. Chem. 283: 28741 - 28746.

• Williams R, Sengerová B, Osborne S, Syson K, Ault S, Kilgour A, Chapados BR, Tainer JA, Sayers JR, Grasby JA. 2007. Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease. J. Mol. Biol. 371: 34 - 38.

• Vijayakumar S, Chapados BR, Schmidt KH, Kolodner RD, Tainer JA, Tomkinson AE. 2007. The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase. Nucleic Acids Research. 35: 1624 - 1637.

• Ivanov I, Chapados BR, McCammon JA, Tainer JA. 2006. Proliferating Cell Nuclear Antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications. Nucleic Acids Research. 34: 6023 - 6033.

• Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR. 2005. Dual modes of RNA-silencing suppression by Flock House virus protein B2. Nat. Struct. Mol. Biol. 12: 952-957.

• Qiu J, Liu R, Chapados BR, Sherman M, Tainer JA, Shen B. 2004. Interaction interface of human flap endonuclease-1 with its DNA substrates. J Biol. Chem. 279: 24394-402.

• Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA. 2004. Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell 116: 39-50.

• Chai Q, Qiu J, Chapados BR, Shen B. 2001. Archaeoglobus fulgidus RNase HII in DNA replication: enzymological functions and activity regulation via metal cofactors. Biochem. Biophys. Res. Commun. 286: 1073-81.

• Chapados BR, Chai Q, Hosfield DJ, Qiu J, Shen B, Tainer JA. 2001. Structural biochemistry of a type II RNase H: RNA Primer recognition and removal during DNA replication. J. Mol. Biol. 307: 541-556.

• Kabza KG, Chapados BR, Gestwicki JE, McGrath JL. 2000. Microwave-induced esterification using heterogeneous acid catalyst in a low dielectric constant medium. J. Org. Chem. 65: 1210-1214.

conferences and workshops

• Braunewell S, Chapados BR, Fallert S, Neugebauer, C.
  Stocastic Modeling of Gene Regulatory Networks. (poster)
  2006 Complex Systems Summer School.
  Santa Fe, NM, June 2006.

• Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA.
  Structural basis for FEN-1 substrate recognition and activation by PCNA. (presentation)
  ACS National Meeting, DNA repair and mutagenesis symposium.
  Washington, D.C., November 2005.

• Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA.
  The role of FEN-1 and PCNA in Okazaki fragment maturation. (presentation)
  Invited Talk, Kyoto University - Laboratories for Integrated Biology.
  Kyoto, Japan, June 2005.

• Chapados BR, Vijayakumar S, Tomkinson AE, Tainer JA.
  Structural Analysis of PCNA binding domain for DNA replication and repair proteins. (poster)
  58th meeting of the Japan Society for Cell Biology.
  Saitama, Japan, June 2005.

• Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA.
  Structural basis for FEN-1 substrate recognition and activation by PCNA. (poster)
  ASM: DNA Repair and Mutagenesis.
  Southampton, Bermuda, November 2004.

• Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA.
  Structural basis for FEN-1 substrate recognition and activation by PCNA. (poster)
  Gordon Conference on Mutagenesis & Carcinogenesis.
  Ventura, CA, March 2004.

• Chapados BR, Hosfield DJ, Qiu J, Yelent B, Shen B, Tainer JA.
  Structural basis of FEN-1 substrate recognition. (poster)
  XVI West Coast Protein Crystallography Workshop.
  Assilomar, CA, March 2003.

• Chapados BR, Chai Q, Hosfield DJ, Qiu J, Shen B, Tainer JA.
  Structural Biochemistry of a Type II RNase H: Insights into RNA primer removal. (poster)
  XV West Coast Protein Crystallography Workshop.
  Assilomar, CA, March 2001.

• Chapados BR, Kabza KG.
  Microwave-induced catalysis using solid-state heterogeneous catalysts. (presentation)
  Eastern Colleges Science Conference.
  Sacred Heart College, CN, April 1999.

awards

• 2005

  Themis Foundation Award for Excellence in Research

• 2000-2004

  NSF Graduate Research Fellowship

• 2002-2005

  Skaggs Institute for Chemical Biology Graduate Fellowship

• 1999

  SUNY Fredonia Chemistry Dept. Award for Outstanding Undergraduate Research

• 1999

  SUNY Chancellor’s Award for Student Excellence

• 1998

  Pfizer Undergraduate Research Fellowship

• 1997-1998

  SUNY Fredonia Scholarship Award

teaching

• 2004-2005

  Mentor to high school student. TSRI

• 1998-1999

  Organic Chemistry Laboratory I&II Teaching Assistant. SUNY Fredonia

• 1997-1999

  Organic Chemistry I&II Recitation Instructor. SUNY Fredonia

• 1997-1999

  Undergraduate Tutor specializing in Science and Mathematics. Learning Center, SUNY Fredonia